Formaldehyde → 2,3,4,5-Tetramethylpyrrole

HRID 1834449Notes

Reaction equation

HRID 1834449 reaction equation

[CH3:1][C:2]1[NH:3][C:4]([CH3:13])=[C:5]([CH3:12])[C:6]=1[C:7](OCC)=O.C=O>>[CH3:1][C:2]1[NH:3][C:4]([CH3:13])=[C:5]([CH3:12])[C:6]=1[CH3:7]

Participants

3

Reactant 2

HCID 712Formaldehyde

HCID 137484Ethyl 2,4,5-trimethyl-1H-pyrrole-3-carboxylate

Product 1

HCID 704842,3,4,5-Tetramethylpyrrole

Procedure

2,4,5-Trimethyl-3-carbethoxy-pyrrole was reductively alkylated using paraformaldehyde to yield tetramethyl pyrrole. ##STR82##

Sources & evidence

ORD record: ord-6365e83bee504479b79de9b240ffc487
Source dataset: uspto-grants-1978_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04070366

Reaction notes

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