Formaldehyde → 1H-Pyrrole, 3-ethyl-2,4,5-trimethyl-

HRID 1834452Notes

Reaction equation

[CH3:1][C:2]1[NH:3][C:4]([C:10](OCC)=O)=[C:5]([CH3:9])[C:6]=1[CH2:7][CH3:8].C=O>>[CH2:7]([C:6]1[C:5]([CH3:9])=[C:4]([CH3:10])[NH:3][C:2]=1[CH3:1])[CH3:8]

Participants

Reactant 2

HCID 712Formaldehyde

HCID 1374803,5-Dimethyl-4-ethyl-1H-pyrrole-2-carboxylic acid ethyl ester

Product 1

HCID 106281H-Pyrrole, 3-ethyl-2,4,5-trimethyl-

Procedure

2,4-Dimethyl-3-ethyl-5-carbethoxy-pyrrole was reductively alkylated with paraformaldehyde to yield 3-ethyl-2,4,5-trimethyl-pyrrole. ##STR85##

Sources & evidence

ORD record: ord-c36a4c5ad81e42129095df4a35e5a1ee
Source dataset: uspto-grants-1978_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04070366

Reaction notes

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