Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | p-Bromoacetophenone | HCID 7466 | — |
| Reactant | Methallyl alcohol | HCID 10557 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | Isobutyraldehyde | HCID 6561 | — |
| Product | p-Bromoacetophenone | HCID 7466 | — |
Reaction Steps
0.2 palladium acetate and 0.48 g triphenyl-phosphine were dissolved in 40 ml dimethylacetamide. Sodium bicarbonate (10 g), 4-bromoacetophenone (19.9g), methallyl alcohol (10.8 g), and diisopropylethylamine (1.0 g) were added and the mixture was heated to 130° C with stirring. After 2 hours, a 100% conversion of 4-bromoacetophenone to 3-Cp-acetylphenyl)-2-methylpropanal was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04070374 |
|---|
| Source dataset | uspto-grants-1978_01 |
|---|
| ORD ID | ord-9ef5a746280c4c319ea8111de6fd1e74 |
|---|
| Source note | uspto-grants-1978_01 |
|---|
