Dimethylformamide → HCID 178485059, compound

HRID 1834565Notes

Reaction equation

HRID 1834565 reaction equation
[N:1]#[C:2][NH2:3].[Pb].[CH3:5][NH:6][C:7]([NH:9][CH2:10][CH2:11][S:12][CH2:13][C:14]1[N:15]=[CH:16][NH:17][CH:18]=1)=S.CN(C)C=O>C(#N)C>[C:2]([NH:3][C:7]([NH:9][CH2:10][CH2:11][S:12][CH2:13][C:14]1[N:15]=[CH:16][NH:17][CH:18]=1)=[N:6][CH3:5])#[N:1]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 22262466CH2N2PbHCID 178486117HCID 178486117, compound

Product 1

HCID 178485059HCID 178485059, compoundYield 31.1%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Lead cyanamide (24.7 g.) was added to a solution of N-methyl-N'-[2-(4-imidazolylmethylthio)ethyl]thiourea (11.5 g.) in acetonitrile (250 ml.) containing dimethylformamide. The stirred suspension was heated under reflux for 48 hours. Filtration followed by concentration under reduced pressure and purification of the product on a column of silica gel with ethyl acetate-isopropyl alcohol (2.1) as eluant gave N-cyano-N'-[2-(4-imidazolylmethylthio)ethyl]-N"-methylguanidine (3.7 g.), m.p. 138°-140° (from acetonitrile).

Workup

  1. temperatureThe stirred suspension was heated
  2. temperatureunder reflux for 48 hours
  3. filtrationFiltration
  4. concentrationfollowed by concentration under reduced pressure and purification of the product on a column of silica gel with ethyl acetate-isopropyl alcohol (2.1) as eluant

Sources & evidence

ORD record
ord-e189d8d2ac4341d1b624a13eea80f0aa
Source dataset
uspto-grants-1978_01
Patent number
US04070475

Reaction notes

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