反应详情

(2-Chloro-4-butyrylphenoxy)acetic acid (12.8 g., 0.05 mole), paraformaldehyde (1.65 g., 0.055 mole), dimethylamine hydrochloride (4.62 g., 0.056 mole) and acetic acid (1ml.) are combined and heated on a steam bath for three hours. The reaction mixture is treated with ethyl alcohol (75 ml.) and ether (125 ml.) which causes precipitation of 11.7 g. (69%) of [2-chloro-4-(2-dimethylaminomethylbutyryl)phenoxy]acetic acid hydrochloride which melts at 182° C. after recrystallization from 2-propanol (90 ml.).

1. temperatureheated on a steam bath for three hours
2. customprecipitation of 11.7 g
3. custom(69%) of [2-chloro-4-(2-dimethylaminomethylbutyryl)phenoxy]acetic acid hydrochloride which melts at 182° C. after recrystallization from 2-propanol (90 ml.)