Bromine → HCID 20373853, compound

HRID 1834672Notes

Reaction equation

HRID 1834672 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:12][CH2:13][C:14]([OH:16])=[O:15])=[C:8]([Cl:11])[CH:9]=2)[CH2:4][CH:3]1[CH2:17][CH3:18].[Br:19]Br>Br.C(O)(=O)C>[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:12][CH2:13][C:14]([OH:16])=[O:15])=[C:8]([Cl:11])[CH:9]=2)[CH2:4][C:3]1([Br:19])[CH2:17][CH3:18]

Participants

5

Reactant 2

HCID 24408BromineHCID 20373854HCID 20373854, compound

Product 1

HCID 20373853HCID 20373853, compound

Reagents, catalysts & solvents 2

HCID 260Hydrogen BromideCatalystHCID 176Acetic AcidSolvent

Procedure

(1-Oxo-2-bromo-2-ethyl-6-chloro-5-indanyloxy)acetic acid is prepared by following substantially the same procedure as described in Example 1, Step B, using the following reagents: (1-oxo-2-ethyl-6-chloro-5-indanyloxy)acetic acid (13.44 g., 0.05 mole), bromine (8.79 g., 0.055 mole), acetic acid (135 ml.) and 48% hydrobromic acid (2 drops). The crude yield of the product is 17.38 g. (100%), m.p. 157°-159° C. Recrystallization from benzene gives (1-oxo-2-bromo-2-ethyl-6-chloro-5-indanyloxy)acetic acid as white needles, m.p. 159.5°-160.5° C.

Workup

  1. custom(1-Oxo-2-bromo-2-ethyl-6-chloro-5-indanyloxy)acetic acid is prepared
  2. customRecrystallization from benzene

Sources & evidence

ORD record
ord-6ed6788ed5054733a91227c8a0d78802
Source dataset
uspto-grants-1978_01
Patent number
US04070539

Reaction notes

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