Bromine → HCID 20373892, compound

HRID 1834673Notes

Reaction equation

HRID 1834673 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[C:6]([CH3:18])[C:7]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[C:8]([CH3:12])[C:9]=2[CH3:11])[CH2:4][CH:3]1[CH2:19][CH3:20].[Br:21]Br>Br.C(O)(=O)C>[O:1]=[C:2]1[C:10]2[C:5](=[C:6]([CH3:18])[C:7]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[C:8]([CH3:12])[C:9]=2[CH3:11])[CH2:4][C:3]1([Br:21])[CH2:19][CH3:20]

Participants

5

Reactant 2

HCID 24408BromineHCID 20373916HCID 20373916, compound

Product 1

HCID 20373892HCID 20373892, compound

Reagents, catalysts & solvents 2

HCID 260Hydrogen BromideCatalystHCID 176Acetic AcidSolvent

Procedure

(1-Oxo-2-bromo-2-ethyl-4,6,7-trimethyl-5-indanyloxy)-acetic acid is prepared by following substantially the same procedure as described in Example 1, Step B, using the following reagents: (1-oxo-2-ethyl-4,6,7-trimethyl-5-indanyloxy)-acetic acid (11.79 g., 0.0427 mole), bromine (7.51 g., 0.0470 mole), acetic acid (118 ml.) and 48% hydrobromic acid (2 drops). The crude yield is 14.76 g. (97%). Recrystallization from butyl chloride give (1-oxo-2-bromo-2-ethyl-4,6,7-trimethyl-5-indanyloxy)acetic acid as white prisms, m.p. 144°-145° C.

Workup

  1. custom(1-Oxo-2-bromo-2-ethyl-4,6,7-trimethyl-5-indanyloxy)-acetic acid is prepared
  2. customRecrystallization from butyl chloride

Sources & evidence

ORD record
ord-07f1e743826a4c819a89949a6fca02a6
Source dataset
uspto-grants-1978_01
Patent number
US04070539

Reaction notes

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