Bromine → HCID 20373866, compound

HRID 1834675Notes

Reaction equation

HRID 1834675 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[C:8]([CH3:12])[C:9]=2[CH3:11])[CH2:4][CH:3]1[CH2:18][CH3:19].[Br:20]Br>Br.C(O)(=O)C>[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[C:8]([CH3:12])[C:9]=2[CH3:11])[CH2:4][C:3]1([Br:20])[CH2:18][CH3:19]

Participants

5

Reactant 2

HCID 24408BromineHCID 12395537HCID 12395537, compound

Product 1

HCID 20373866HCID 20373866, compound

Reagents, catalysts & solvents 2

HCID 260Hydrogen BromideCatalystHCID 176Acetic AcidSolvent

Procedure

By following substantially the same procedure as described in Example 1, Step B, using as the reactants (1-oxo-2-ethyl-6,7-dimethyl-5indanyloxy)acetic acid (10.5 g., 0.04 mole), bromine (6.4 g., 0.04 mole), acetic acid (125 ml.) and 48% aqueous hydrobromic acid (2 drops), there is obtained 8.6 g. (63%) of (1oxo-2bromo-2-ethyl-6,7-dimethyl-5-indanyloxy)acetic acid which melts at 136°-139° C. after recrystallization from butyl chloride (200 ml.).

Workup

  1. customthere is obtained 8.6 g
  2. custom(63%) of (1oxo-2bromo-2-ethyl-6,7-dimethyl-5-indanyloxy)acetic acid which melts at 136°-139° C. after recrystallization from butyl chloride (200 ml.)

Sources & evidence

ORD record
ord-b92d08c6afd24afebe66f1275bed9b13
Source dataset
uspto-grants-1978_01
Patent number
US04070539

Reaction notes

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