Benzaldehyde → HCID 54411900, compound

HRID 1834691Notes

Reaction equation

HRID 1834691 reaction equation
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:9][C:10]1[C:15]([Cl:16])=[C:14]([O:17][CH3:18])[CH:13]=[CH:12][C:11]=1[C:19](=[O:23])[CH2:20][CH2:21][CH3:22].[OH-].[Na+]>C(O)C>[Cl:16][C:15]1[C:10]([Cl:9])=[C:11]([C:19](=[O:23])[C:20](=[CH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:21][CH3:22])[CH:12]=[CH:13][C:14]=1[O:17][CH3:18]

Participants

5

Reactant 3

HCID 240BenzaldehydeHCID 14798Sodium HydroxideHCID 12395545HCID 12395545, compound

Product 1

HCID 54411900HCID 54411900, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of benzaldehyde (19.4 g., 0.183 mole) and 2',3'-dichloro-4'-methoxybutyrophenone (42.2 g., 0.183 mole) in absolute ethanol (350 ml.) a 20% sodium hydroxide solution (35.9 ml.) is added dropwise with stirring. The mixture is stirred for 22 hours. The white solid product that separates is collected and air dried. Yield 55.6 g. (91%), m.p. 127°-130° C.

Workup

  1. additionis added dropwise
  2. stirringThe mixture is stirred for 22 hours
  3. customThe white solid product that separates is collected
  4. customair dried

Sources & evidence

ORD record
ord-95f6565ca509408e90149cdc25d560a7
Source dataset
uspto-grants-1978_01
Patent number
US04070539

Reaction notes

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