反应详情

温度

30 °C

To 8.6 g. piloty acid dissolved in 50 ml. methanol, propargyl bromine (6.6 g.) was added. 10.8 g. sodium methoxide (25%) was added slowly dropwise. An exothermic reaction resulted, the temperature was maintained at 30° C. The reaction mixture was stirred for approximately 1 hour at room temperature. The solvent was removed in vacuo. There was obtained a yellow solid. This material was treated with ether and the solid filtered off and dried. There was obtained 3.1 g. of the title compound, a low melting solid.

1. customAn exothermic reaction
2. customresulted
3. customThe solvent was removed in vacuo
4. customThere was obtained a yellow solid
5. filtrationthe solid filtered off
6. customdried
7. customThere was obtained 3.1 g