Thioglycolic Acid → Ninhydrin

HRID 1834755Notes

Reaction equation

HRID 1834755 reaction equation
N[C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH2:4]SC.Cl[CH2:11][CH2:12][CH:13](N)[C:14](O)=O.[CH3:18][O:19]CCC(N)C(O)=O.N[C@H](C([OH:33])=S)CS.C(O)(=S)C.C(O)(=O)CS.C(O)(=S)C(C)O>>[CH:12]1[CH:11]=[C:3]2[C:2]([C:7]([OH:9])([OH:8])[C:18](=[O:19])[C:4]2=[CH:14][CH:13]=1)=[O:33]

Participants

8

Reactant 7

HCID 1133Thioglycolic AcidHCID 6137L-MethionineHCID 18713O-MethylhomoserineHCID 19391794HCID 19391794, compoundHCID 178418634HCID 178418634, compoundHCID 178473673HCID 178473673, compoundHCID 178511840HCID 178511840, compound

Product 1

HCID 10236Ninhydrin

Procedure

In a manner analogous to that mentioned above, L-methionine, γ-chloro-α-amino butyric acid, and γ-methoxy-α-amino butyric acid were contacted each with thiocysteine, γ-cresol, thioacetic acid, thioglycolic acid and thiolactic acid. Rf of the ninhydrin positive spot of the compounds produced were different from L-methionine, γ-chloro-α-amino butyric acid, and γ-methoxy-α-amino butyric acid, and thus new amino acids were produced.

Sources & evidence

ORD record
ord-2acddceeb7964f28a7b8d77b67c3335e
Source dataset
uspto-grants-1978_01
Patent number
US04071405

Reaction notes

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