反应详情

Into a flask containing 7.0 g. of 7-carboxy-1-isopropyl-4-(m-methoxyphenyl)-2(1H)-quinazolinone dissolved in anhydrous methanol is introduced hydrogen chloride gas until the temperature reaches 50° C. The flask is then equipped with a stopper and the reaction mixture allowed to stand under ambient conditions for 7 hours. The resulting mixture is evaporated to dryness, the residue taken up in benzene, washed with water, followed by evaporation to dryness and crystallization of the residue from methanol to obtain 7-carbomethoxy-1-isopropyl-4-(m-methoxyphenyl)-2(1H)-quinazolinone, m.p. 164°-167° C.

1. additionInto a flask containing 7.0 g
2. customreaches 50° C
3. customThe flask is then equipped with a stopper
4. customThe resulting mixture is evaporated to dryness
5. washwashed with water
6. customfollowed by evaporation to dryness and crystallization of the residue from methanol