Fumaric Acid → HCID 13370452, compound

HRID 1834783Notes

Reaction equation

HRID 1834783 reaction equation
[F:1][C:2]([F:31])([F:30])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]([F:16])([F:15])[F:14])=[CH:7][C:6]=1[NH:17][C:18]([N:20]([CH2:28][CH3:29])[CH2:21][CH:22]1[CH2:26][CH2:25][CH2:24][N:23]1[CH3:27])=[O:19].[C:32]([OH:39])(=[O:38])/[CH:33]=[CH:34]/[C:35]([OH:37])=[O:36]>C(OCC)C>[C:32]([OH:39])(=[O:38])/[CH:33]=[CH:34]/[C:35]([OH:37])=[O:36].[F:31][C:2]([F:1])([F:30])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]([F:15])([F:16])[F:14])=[CH:7][C:6]=1[NH:17][C:18]([N:20]([CH2:28][CH3:29])[CH2:21][CH:22]1[CH2:26][CH2:25][CH2:24][N:23]1[CH3:27])=[O:19]

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 13370451HCID 13370451, compound

Product 1

HCID 13370452HCID 13370452, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A sample of N-[2,5-bis(2,2,2-trifluoroethoxy)phenyl]-N'-ethyl-N'-[(1-methylpyrrolidin-2-yl)methyl]urea is dissolved in diethyl ether and treated with an ether solution of an equimolar amount of fumaric acid to provide a solid which is separated by filtration. The product is recrystallized from ethyl acetate to provide N-[2,5-bis(2,2,2-trifluoroethoxy)phenyl]-N'-ethyl-N'-[(1-methylpyrrolidin-2-yl)methyl]urea fumarate, m.p. 138° C. (dec.).

Workup

  1. customto provide a solid which
  2. customis separated by filtration
  3. customThe product is recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-4a2b742c9b0b458cb1354d66d5a7c00e
Source dataset
uspto-grants-1978_01
Patent number
US04071524

Reaction notes

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