Fumaric Acid → HCID 13370452, compound

Participants

Reaction Steps

A sample of N-[2,5-bis(2,2,2-trifluoroethoxy)phenyl]-N'-ethyl-N'-[(1-methylpyrrolidin-2-yl)methyl]urea is dissolved in diethyl ether and treated with an ether solution of an equimolar amount of fumaric acid to provide a solid which is separated by filtration. The product is recrystallized from ethyl acetate to provide N-[2,5-bis(2,2,2-trifluoroethoxy)phenyl]-N'-ethyl-N'-[(1-methylpyrrolidin-2-yl)methyl]urea fumarate, m.p. 138° C. (dec.).

Provenance & Evidence