Ethyl formate → HCID 21515920, compound

HRID 1834854Notes

Reaction equation

HRID 1834854 reaction equation
[F:1][C:2]([C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][NH2:16])([F:12])[C:3]([F:11])([F:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH:21](OCC)=[O:22]>>[F:1][C:2]([C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][NH:16][CH:21]=[O:22])([F:12])[C:3]([F:11])([F:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 203722482-(alpha,alpha,beta,beta-Tetrafluorophenethyl)benzylamine

Product 1

HCID 21515920HCID 21515920, compound

Procedure

2-(α, α, β, β-Tetrafluorophenethyl)benzylamine, 1.4 g. (0.005 mole), in 100 ml. of ethyl formate, is stirred and heated to refluxing for about 20 hours. Evaporation of the solution to dryness and trituration of the residual solid with petroleum ether gives N-[2-(α, α, β, β-tetrafluorophenethyl)benzyl]formamide, m.p. 61°-75° C.

Workup

  1. temperatureheated
  2. temperatureto refluxing for about 20 hours
  3. customEvaporation of the solution to dryness and trituration of the residual solid with petroleum ether

Sources & evidence

ORD record
ord-9e83aca5fc994393a6ff79eda389d245
Source dataset
uspto-grants-1978_01
Patent number
US04071570

Reaction notes

Loading…