Hydrochloric Acid → HCID 20372282, compound

Participants

Reaction Steps

By following essentially the same procedures described in Example 6, N-[α,α-dimethyl-4-(p-methyl-α,α,β,β-tetrafluorophenethyl)-benzyl]-formamide is reduced to 4-(p-methyl-α,α,β,β-tetrafluorophenethyl)-α,αN-trimethylbenzylamine. The crude oily base is converted to the hydrochloride salt by treating a solution in ethanol with a slight excess of 8N hydrogen chloride in ethanol. Dilution with absolute ether precipitates the white crystalline hydrochloride, m.p. 189°-190° C. The melting point is unchanged by recrystallization from isopropyl alcohol-ether.

Provenance & Evidence