Hydrochloric Acid → HCID 20372282, compound

HRID 1834870Notes

Reaction equation

HRID 1834870 reaction equation
[CH3:1][C:2]([NH:23][CH:24]=O)([CH3:22])[C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:21])([F:20])[C:10]([F:19])([F:18])[C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)=[CH:5][CH:4]=1.Cl>C(O)C>[CH3:17][C:14]1[CH:13]=[CH:12][C:11]([C:10]([F:19])([F:18])[C:9]([C:6]2[CH:7]=[CH:8][C:3]([C:2]([NH:23][CH3:24])([CH3:22])[CH3:1])=[CH:4][CH:5]=2)([F:20])[F:21])=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20372213HCID 20372213, compound

Product 1

HCID 20372282HCID 20372282, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

By following essentially the same procedures described in Example 6, N-[α,α-dimethyl-4-(p-methyl-α,α,β,β-tetrafluorophenethyl)-benzyl]-formamide is reduced to 4-(p-methyl-α,α,β,β-tetrafluorophenethyl)-α,αN-trimethylbenzylamine. The crude oily base is converted to the hydrochloride salt by treating a solution in ethanol with a slight excess of 8N hydrogen chloride in ethanol. Dilution with absolute ether precipitates the white crystalline hydrochloride, m.p. 189°-190° C. The melting point is unchanged by recrystallization from isopropyl alcohol-ether.

Workup

  1. customDilution with absolute ether precipitates the white crystalline hydrochloride, m.p. 189°-190° C
  2. customThe melting point is unchanged by recrystallization from isopropyl alcohol-ether

Sources & evidence

ORD record
ord-6af65fa3881040c7ac1539535e18e6d6
Source dataset
uspto-grants-1978_01
Patent number
US04071570

Reaction notes

Loading…