Potassium sodium tartarate → 1,5-Androstadiene-3beta,17beta-diol

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Reaction Steps

A tetrahydrofuran solution of the 1,5-androstadiene-3,17-dione so prepared is added to a solution of lithium tri-t-butoxyaluminum hydride in tetrahydrofuran. After stirring overnight at room temperature, an aqueous solution of potassium sodium tartrate is added with stirring to form a readily filterable white solid. The reaction mixture is filtered. The filtrate is dried over magnesium sulfate, the solvent removed and the residue is recrystallized from acetone to yield 1,5-androstadiene-3β,17β-diol.

Provenance & Evidence