反应详情

A tetrahydrofuran solution of the 1,5-androstadiene-3,17-dione so prepared is added to a solution of lithium tri-t-butoxyaluminum hydride in tetrahydrofuran. After stirring overnight at room temperature, an aqueous solution of potassium sodium tartrate is added with stirring to form a readily filterable white solid. The reaction mixture is filtered. The filtrate is dried over magnesium sulfate, the solvent removed and the residue is recrystallized from acetone to yield 1,5-androstadiene-3β,17β-diol.

1. stirringwith stirring
2. customto form a readily filterable white solid
3. filtrationThe reaction mixture is filtered
4. dry with materialThe filtrate is dried over magnesium sulfate
5. customthe solvent removed
6. customthe residue is recrystallized from acetone