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HRID1834967

反应详情

EQUATION

反应方程式

HRID 1834967 的结构方程式

REACTANTS

反应物

3
结构：c1ccncc1
HCID1049

Pyridine

C5H5N

结构：C[Si](C)(C)Cl
HCID6397

Chlorotrimethylsilane

C3H9ClSi

结构：C[C@H]1CC(=O)C[C@@H]2CC[C@H]3[C@@H]4CC[C@H](O)[C@@]4(C)CC[C@@H]3[C@]21CO
HCID70615096

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H]1CC(=O)C[C@@H]2CC[C@H]3[C@@H]4CC[C@H](O[Si](C)(C)C)[C@@]4(C)CC[C@@H]3[C@]21CO[Si](C)(C)C
HCID22801533

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccccc1
溶剂HCID241

Benzene

C6H6

PROCEDURE

实验过程

A mixture of 17β,19-dihydroxy-1α-methyl-5α-androstan-3-one, trimethylchlorosilane and pyridine in benzene is heated to its reflux temperature for a period of about 14 hours. The reaction mixture is vacuum filtered, the organic layer is washed with water, dried over magnesium sulfate and concentrated in vacuum. Crystallization of the residue from hexane yields 1α-methyl-17β,19-di(trimethylsiloxy)-5α-androstan-3-one.

WORKUP

后处理

  1. temperatureis heated to its
  2. temperaturereflux temperature for a period of about 14 hours
  3. filtrationfiltered
  4. washthe organic layer is washed with water
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated in vacuum
  7. customCrystallization of the residue from hexane