HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 1alpha-Methyl-17beta,19-di(trimethylsiloxy)-5alpha-androstan-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 17beta,19-Dihydroxy-1alpha-methyl-5alpha-androstan-3-one | HCID 70615096 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 1alpha-Methyl-17beta,19-di(trimethylsiloxy)-5alpha-androstan-3-one | HCID 22801533 | — |
Reaction Steps
A mixture of 17β,19-dihydroxy-1α-methyl-5α-androstan-3-one, trimethylchlorosilane and pyridine in benzene is heated to its reflux temperature for a period of about 14 hours. The reaction mixture is vacuum filtered, the organic layer is washed with water, dried over magnesium sulfate and concentrated in vacuum. Crystallization of the residue from hexane yields 1α-methyl-17β,19-di(trimethylsiloxy)-5α-androstan-3-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04071625 |
| Source dataset | uspto-grants-1978_01 |
| ORD ID | ord-c9260c3151d44116bb965af33edb6bef |
| Source note | uspto-grants-1978_01 |