Potassium sodium tartarate → 1,5-Androstadiene-3beta,17beta-diol

Participants

Reaction Steps

A tetrahydrofuran solution of 1,5-androstadiene-3,17-dione is added to a solution of lithium tri-t-butoxyaluminum hydride in tetrahydrofuran under nitrogen. After stirring overnight at room temperature, an aqueous solution of potassium sodium tartrate is added with stirring to form a readily filterable white solid. The reaction mixture is filtered and the filtrate dried over magnesium sulfate. The solvent is removed and the residue recrystallized from acetone to yield 1,5-androstadiene-3β,17β-diol.

Provenance & Evidence