反应详情

A tetrahydrofuran solution of 1,5-androstadiene-3,17-dione is added to a solution of lithium tri-t-butoxyaluminum hydride in tetrahydrofuran under nitrogen. After stirring overnight at room temperature, an aqueous solution of potassium sodium tartrate is added with stirring to form a readily filterable white solid. The reaction mixture is filtered and the filtrate dried over magnesium sulfate. The solvent is removed and the residue recrystallized from acetone to yield 1,5-androstadiene-3β,17β-diol.

1. stirringwith stirring
2. customto form a readily filterable white solid
3. filtrationThe reaction mixture is filtered
4. dry with materialthe filtrate dried over magnesium sulfate
5. customThe solvent is removed
6. customthe residue recrystallized from acetone