HuagongsheHuagongshe Chemistry Print Report · For research reference only
19-Tetrahydropyranyloxy-4-androstene-3,17-dione → 19-Tetrahydropyranyloxy-5alpha-androstane-3,17-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 19-Tetrahydropyranyloxy-4-androstene-3,17-dione | HCID 10091561 | — |
| Reactant | 19-Trimethylsiloxy-4-androstene-3,17-dione | HCID 22801497 | — |
| Product | 19-Tetrahydropyranyloxy-5alpha-androstane-3,17-dione | HCID 22801526 | — |
| Product | 19-Trimethylsiloxy-5alpha-androstane-3,17-dione | HCID 22801527 | — |
Reaction Steps
Substituting 17β-hydroxy-4,6α,17α-trimethyl-4-androstene-3,19-dione, 17β-hydroxy-4,6α,17α-trimethyl-4-androstene-3,19-dione acetate, 19-tetrahydropyranyloxy-4-androstene-3,17-dione, 19-trimethylsiloxy-4-androstene-3,17-dione and 6α-methyl-19-(2'-tetrahydropyranyloxy)-4-androstene-3,17-dione for the 4,6α,17α-trimethyl-17β,19-di(2'-tetrahydropyranyloxy)-4-androsten-3-one above results in the preparation of 17β-hydroxy-4,6α,17α-trimethyl-5α-androstane-3,19-dione, 17β-hydroxy-4,6α,17α-trimethyl-5α-androstane-3,19-dione acetate, 19-tetrahydropyranyloxy-5α-androstane-3,17-dione, 19-trimethylsiloxy-5α-androstane-3,17-dione and 6α-methyl-19-(2'-tetrahydropyranyloxy)-5α-androstane-3,17-dione, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04071625 |
| Source dataset | uspto-grants-1978_01 |
| ORD ID | ord-a0eba5d30e194821829d06106c589a9a |
| Source note | uspto-grants-1978_01 |