Hydrochloric Acid → HCID 178484881、化合物

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Detection and Quantification of Methamphetamine using a Reactive Coating on Silver Foil: Silver foil was roughened and etched (Example 1d) followed by dip-coating in an methanol solution of MNA/methamphetamine containing 2 ppm of a CH2Cl2 solution of pentachlorothiolphenol (PCTP). The PCTP was used as an internal standard for quantification purposes. The coated foil surfaces were rinsed with ethanol to remove unbound MNA/methamphetamine and PCTP. The MNA/methamphetamine was synthesized by dissolving 186 mg methamphetamine hydrochloride in 15 mL of saturated aqueous K2CO3 to neutralize the hydrochloride. The freebase was then extracted from the aqueous solution using diethyl ether (Et2O). The ether was removed under reduced pressure and the methamphetamine re-dissolved in 8 mL of ethanol to which was added 169 mg 2-mercaptonicotinic acid (MNA) and 228 mg dicyclohexylcarbodiimide (DCC) in 2mL H2O. The reaction was gently refluxed under a nitrogen atmosphere for 2 hr. The MNA/methamphetamine reaction product was transferred to a separatory funnel using Et2O and extracted with additional Et2O followed by washes with saturated aqueous NaHCO3, H2O, and 10% HCI. Solvent was removed under reduced pressure. The product N-methyl-N-(1-methyl-2-phenylethyl)-2-mercaptopyridine-3-carboxamide (MNA/methamphetamine) was re-dissolved in methanol to form standard solutions in the concentration range of 0 ppm to 2500 ppm. SERS spectra were obtained from the MNA/methamphetamine/PCTP coated silver foil surfaces.

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