反应详情

The (1R,6S)-l-(2,2,6-trimethylcyclohexyl)-ethan-1-ol (15b) (250 g) synthesized in Reference Example 4 and a copper-chromium catalyst (12.5 g) pre-activated with hydrogen were placed in a 500 ml, 4-necked flask equipped with a thermometer, condenser and stirrer, followed by reacting at 200° C. for 6 hours. After cooling the reaction mixture and filtering out the catalyst, the reaction liquid was distilled with a Widmer distiller to obtain 224 g of (1R,6S)-2,2,6-trimethylcyclohexyl methyl ketone (1b) (b.p.: 76-78° C./1197 Pa (9 torr)).

1. customequipped with a thermometer, condenser and stirrer
2. temperatureAfter cooling the reaction mixture
3. filtrationfiltering out the catalyst
4. customthe reaction liquid
5. distillationwas distilled with a Widmer distiller