(1R,6S)-1-(2,2,6-trimethylcyclohexyl)-ethan-1-ol → Ethanone, 1-((1R,6S)-2,2,6-trimethylcyclohexyl)-, rel-

참여 물질

반응 단계

The (1R,6S)-l-(2,2,6-trimethylcyclohexyl)-ethan-1-ol (15b) (250 g) synthesized in Reference Example 4 and a copper-chromium catalyst (12.5 g) pre-activated with hydrogen were placed in a 500 ml, 4-necked flask equipped with a thermometer, condenser and stirrer, followed by reacting at 200° C. for 6 hours. After cooling the reaction mixture and filtering out the catalyst, the reaction liquid was distilled with a Widmer distiller to obtain 224 g of (1R,6S)-2,2,6-trimethylcyclohexyl methyl ketone (1b) (b.p.: 76-78° C./1197 Pa (9 torr)).

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