HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylhydrazine → 2-methyl-4-(2-methylpropyl)-1H,2H,6H-pyrrolo[3,4-d]pyridazin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylhydrazine | HCID 6061 | — |
| Reactant | methyl 4-(3-methylbutanoyl)-1H-pyrrole-3-carboxylate | HCID 5282540 | — |
| Product | 2-methyl-4-(2-methylpropyl)-1H,2H,6H-pyrrolo[3,4-d]pyridazin-1-one | HCID 135524784 | — |
Reaction Steps
Methyl 4-(3-methyl-1-oxobutyl)-1H-pyrrole-3-carboxylate (Example 1, step b, 7.8 g) and methylhydrazine (6 ml) were heated at reflux for 18 hours. The solvent was evaporated and the residue was chromatographed, eluting with dichloromethane-ethanol (19:1), to give the sub-title compound as a sand coloured solid (5.2 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06770646B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-b630b1f73946440884db9723a32ee3bf |
| Source note | uspto-grants-2004_08 |