Tetrabutylammonium Fluoride → HCID 9922101, compound

HRID 1835177Notes

Reaction equation

HRID 1835177 reaction equation
C([Si](C)(C)[O:6][CH2:7][CH2:8][CH2:9][N:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]([C:19]2[NH:27][C:22]3=[N:23][CH:24]=[CH:25][N:26]=[C:21]3[CH:20]=2)=[CH:11]1)(C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[N:26]1[CH:25]=[CH:24][N:23]=[C:22]2[NH:27][C:19]([C:12]3[C:13]4[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=4)[N:10]([CH2:9][CH2:8][CH2:7][OH:6])[CH:11]=3)=[CH:20][C:21]=12

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 22477185HCID 22477185, compound

Product 1

HCID 9922101HCID 9922101, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of 6-{1-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-1H-indol-3-yl}-5H-pyrrolo[2,3-b]pyrazine [29 g, Reference Example 3(a)] in tetrahydrofuran (500 mL) under nitrogen was treated with a solution of tetrabutylammonium fluoride in tetrahydrofuran (144 mL, 1.0M).

Sources & evidence

ORD record
ord-52830afdd16c434fb33833af41c8ed9a
Source dataset
uspto-grants-2004_08
Patent number
US06770643B2

Reaction notes

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