Water → HCID 22477321, compound

HRID 1835201Notes

Reaction equation

HRID 1835201 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[NH:19][C:14]3=[N:15][CH:16]=[CH:17][N:18]=[C:13]3[C:12]=2[CH2:20][CH2:21][CH2:22][NH2:23])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:24]([N:27]=[C:28]=[O:29])[CH2:25][CH3:26].O>O1CCCC1>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[NH:19][C:14]3=[N:15][CH:16]=[CH:17][N:18]=[C:13]3[C:12]=2[CH2:20][CH2:21][CH2:22][NH:23][C:28]([NH:27][CH2:24][CH2:25][CH3:26])=[O:29])=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 962WaterHCID 61033Propyl isocyanateHCID 22477209HCID 22477209, compound

Product 1

HCID 22477321HCID 22477321, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 3-(6-(4-tert-butylphenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)propylamine (0.0324 mmol) [Example 24] in tetrahydrofuran (2 mL) was treated with n-propyl-isocyanate (0.0324 mmol). The solution was stirred at room temperature for 12 hours and then treated with water (3 mL). The resulting precipitate was filtered, then washed with water and then dried under vacuum at 50° C. to give the title compound as a beige solid. MS: 394 (MH+). HPLC (Method C): RT=3.25 minutes.

Workup

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with water
  3. customdried under vacuum at 50° C.

Sources & evidence

ORD record
ord-4a1cee1af8464db0995a227f3c6428e0
Source dataset
uspto-grants-2004_08
Patent number
US06770643B2

Reaction notes

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