反应详情

A solution of 1-{1-(R)-[4-(3,4-dichlorobenzyl)piperidin-1-ylmethyl]-2-methylpropyl}-3-(3,4,5-trimethoxyphenyl)urea (0. 19 g, 0.353 mmoles) in iodoethane (4 ml) was stirred overnight at 68° C. degrees under argon. The yellow mixture was concentrated in vacuo and the crude product was flash chromatographed, eluting with 3%-4% methanol/methylene chloride to give 4-(3,4-dichlorobenzyl)-1-ethyl-1-{3-methyl-2-[3-(3,4,5-trimethoxyphenyl)ureido]butyl}piperidinium iodide (0.18 g) as a yellow solid.

1. concentrationThe yellow mixture was concentrated in vacuo
2. customchromatographed
3. washeluting with 3%-4% methanol/methylene chloride