(4-Fluoro-2-methylphenyl)boronic acid → 2-(3,5-Bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyrid-3-yl)-N,2-dimethylpropanamide

HRID 1835337Notes

Reaction equation

HRID 1835337 reaction equation
[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([C:13]([CH3:33])([CH3:32])[C:14]([N:16]([C:18]2[CH:19]=[N:20][C:21]([Cl:31])=[CH:22][C:23]=2C2C=CC=CC=2Cl)[CH3:17])=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[F:36][C:37]1[CH:42]=[CH:41][C:40](B(O)O)=[C:39]([CH3:46])[CH:38]=1>>[F:12][C:9]([F:10])([F:11])[C:7]1[CH:6]=[C:5]([C:13]([CH3:32])([CH3:33])[C:14]([N:16]([C:18]2[CH:19]=[N:20][C:21]([Cl:31])=[CH:22][C:23]=2[C:40]2[CH:41]=[CH:42][C:37]([F:36])=[CH:38][C:39]=2[CH3:46])[CH3:17])=[O:15])[CH:4]=[C:3]([C:2]([F:34])([F:35])[F:1])[CH:8]=1

Participants

3

Reactant 2

HCID 2734665(4-Fluoro-2-methylphenyl)boronic acidHCID 23502837HCID 23502837, compound

Product 1

HCID 235027842-(3,5-Bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyrid-3-yl)-N,2-dimethylpropanamide

Procedure

The title compound is prepared according to the procedures described above for the preparation of 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide (Example 24) using (4-fluoro-2-methylphenyl)boronic acid instead of 2-chlorophenylboronic acid in step c).

Sources & evidence

ORD record
ord-19b8bff1d5194bdfabc0526c3420c771
Source dataset
uspto-grants-2004_08
Patent number
US06770637B2

Reaction notes

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