(4-Fluoro-2-methylphenyl)boronic acid → 2-(3,5-Bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyrid-3-yl)-N,2-dimethylpropanamide

Participants

Role	Name	HCID	Charge
Reactant	(4-Fluoro-2-methylphenyl)boronic acid	HCID 2734665	—
Reactant	2-[3,5-bis(trifluoromethyl)phenyl]-N-[6-chloro-4-(2-chlorophenyl)-3-pyridinyl]-N,2-dimethylpropanamide	HCID 23502837	—
Product	2-(3,5-Bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyrid-3-yl)-N,2-dimethylpropanamide	HCID 23502784	—

Reaction Steps

The title compound is prepared according to the procedures described above for the preparation of 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide (Example 24) using (4-fluoro-2-methylphenyl)boronic acid instead of 2-chlorophenylboronic acid in step c).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06770637B2
Source dataset	uspto-grants-2004_08
ORD ID	ord-19b8bff1d5194bdfabc0526c3420c771
Source note	uspto-grants-2004_08