(2-Methyl-4,5-(methylenedioxy)phenyl)(2-chloro-4-trifluoromethyl-3-pyridyl)methanol → 3-[4,5-(Methylenedioxy)-2-methylbenzoyl]-2-chloro-4-trifluoromethylpyridine

HRID 1835406Notes

Reaction equation

HRID 1835406 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]2[O:8][CH2:9][O:10][C:5]2=[CH:4][C:3]=1[CH:11]([C:13]1[C:14]([Cl:23])=[N:15][CH:16]=[CH:17][C:18]=1[C:19]([F:22])([F:21])[F:20])[OH:12]>[O-2].[O-2].[Mn+4]>[CH2:9]1[O:10][C:5]2[C:6](=[CH:7][C:2]([CH3:1])=[C:3]([CH:4]=2)[C:11]([C:13]2[C:14]([Cl:23])=[N:15][CH:16]=[CH:17][C:18]=2[C:19]([F:21])([F:22])[F:20])=[O:12])[O:8]1

Participants

3

Reactant 1

HCID 23503597(2-Methyl-4,5-(methylenedioxy)phenyl)(2-chloro-4-trifluoromethyl-3-pyridyl)methanol

Product 1

HCID 235035943-[4,5-(Methylenedioxy)-2-methylbenzoyl]-2-chloro-4-trifluoromethylpyridineYield 22%

Reagents, catalysts & solvents 1

HCID 178418406HCID 178418406, compoundCatalyst

Procedure

Using 1.5 g (4.3 mmol) of (2-methyl-4,5-(methylenedioxy)phenyl)(2-chloro-4-trifluoromethyl-3-pyridyl)methanol obtained in step (c) and 8.0 g (92 mmol) of manganese dioxide, 0.3 g (yield 22%) of 3-[4,5-(methylenedioxy)-2-methylbenzoyl]-2-chloro-4-trifluoromethylpyridine (compound No. 13; m.p. 119-122° C.) was obtained by a process in accordance with step (b) of Synthesis Example 1.

Sources & evidence

ORD record
ord-24172ee144fd4130b46971dda77759e1
Source dataset
uspto-grants-2004_08
Patent number
US06770662B2

Reaction notes

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