Potassium Carbonate → HCID 69901207, compound

HRID 1835444Notes

Reaction equation

HRID 1835444 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[CH2:7][C:8]#[N:9])([O-:3])=[O:2].O.[C:14]([OH:18])(=[O:17])[CH:15]=O.C(=O)([O-])[O-].[K+:23].[K+]>CO>[K+:23].[C:8]([C:7]([C:6]1[CH:10]=[CH:11][CH:12]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)=[CH:15][C:14]([O-:18])=[O:17])#[N:9]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 121253-NitrophenylacetonitrileHCID 15620607Glyoxylic acid, monohydrate

Product 1

HCID 69901207HCID 69901207, compoundYield 85.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 3-nitrobenzyl cyanide (1.62 g), glyoxylic acid monohydrate (1.38 g) and potassium carbonate (3.59 g) in methanol (20 ml) was stirred for 5 hours. The precipitate was collected by filtration, washed with dichloromethane and dried. The precipitate was suspended in water and stirred for an hour. The insoluble material was collected by filtration and dried to give 3-cyano-3-(3-nitro-phenyl)-acrylic acid potassium salt (2.18 g, 85.2%).

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with dichloromethane
  3. customdried
  4. stirringstirred for an hour
  5. filtrationThe insoluble material was collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-33e6f6ad422b4b8f8e8527c7ea30be2f
Source dataset
uspto-grants-2004_08
Patent number
US06770667B1

Reaction notes

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