反应详情

温度

80 °C

To a suspension of 5-bromopyrimidine (1.59 g), 4-methyl-3-nitrophenylboronic acid (2.35 g) and tetrakis(triphenylphosphine)-palladium (578 mg) in 1,2-dimethoxyethane (20 ml) was added an aqueous solution of sodium carbonate (2M, 13 ml) followed by stirring at 80° C. for 24 hours. The mixture was diluted with dichloromethane and washed with water and brine. The organic layer was dried over magnesium sulfate and evaporated under reduced pressure. The residue was triturated with methanol. The resulting precipitated was collected by filtration, washed with methanol and diisopropyl ether and dried to give 5-(4-methyl-3-nitrophenyl)-pyrimidine (918 mg, 84.2%).

1. washwashed with water and brine
2. dry with materialThe organic layer was dried over magnesium sulfate
3. customevaporated under reduced pressure
4. customThe residue was triturated with methanol
5. customThe resulting precipitated
6. filtrationwas collected by filtration
7. washwashed with methanol and diisopropyl ether
8. customdried