2-Chlorotrityl chloride → Diisopropylamine

HRID 1835564Notes

Reaction equation

HRID 1835564 reaction equation
[CH2:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C@H:8]([NH:12][C:13]([O:15][CH2:16][CH:17]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[C:23]3[C:18]2=[CH:19][CH:20]=[CH:21][CH:22]=3)=[O:14])[C:9]([OH:11])=[O:10])[CH2:3][CH2:2]1.Cl[C:31]1[CH:50]=[CH:49]C=CC=1C(Cl)(C1C=CC=CC=1)C1C=CC=CC=1>ClCCl>[CH:8]([NH:12][CH:50]([CH3:49])[CH3:31])([CH3:9])[CH3:7].[NH:12]([C:13]([O:15][CH2:16][CH:17]1[C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:24]2[C:29]1=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:14])[C@H:8]([C:9]([OH:11])=[O:10])[CH2:7][CH:4]1[CH2:5][CH2:6][CH2:1][CH2:2][CH2:3]1

Participants

5

Reactant 2

HCID 945242-Chlorotrityl chlorideHCID 978326Fmoc-Cha-OH

Product 2

HCID 7912DiisopropylamineHCID 978326Fmoc-Cha-OH

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Fmoc Cha-OH (1 mmol each time) was double coupled to the chlorotrityl chloride resin in the standard way using, dichloromethane (5 ml each time) with diisopropylamine (2 eq, 348 μl each time) to give Fmoc-Cha-resin.

Sources & evidence

ORD record
ord-b1895a8f4cd14b53a3a943308ffa8083
Source dataset
uspto-grants-2004_08
Patent number
US06770627B1

Reaction notes

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