Bromine → 6-AMINO-1-BENZYL-5-BROMOURACIL

HRID 1835736Notes

Reaction equation

HRID 1835736 reaction equation
[Br:1]Br.[NH2:3][C:4]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8](=[O:17])[NH:7][C:6](=[O:18])[CH:5]=1.C([O-])(=O)C.[Na+]>C(O)(=O)C>[NH2:3][C:4]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8](=[O:17])[NH:7][C:6](=[O:18])[C:5]=1[Br:1]

Participants

5

Reactant 3

HCID 24408BromineHCID 2507466-Amino-1-benzyluracilHCID 517045Sodium Acetate

Product 1

HCID 8221496-AMINO-1-BENZYL-5-BROMOURACIL

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

A solution of bromine (33.17 ml) in acetic acid (300 ml) was added slowly to a solution of 6-amino-1-benzyluracil and anhydrous sodium acetate (93.29 g) in acetic acid (300 ml) and stirred for 6 hours. The reaction mixture was cooled in ice-cold water. The precipitate was filtered and dried under vacuum to provide 6-amino-1-benzyl-5-bromouracil (134.0 g).

Workup

  1. temperatureThe reaction mixture was cooled in ice-cold water
  2. filtrationThe precipitate was filtered
  3. customdried under vacuum

Sources & evidence

ORD record
ord-6e60c33df26d4ed98f27d48becedd096
Source dataset
uspto-grants-2004_08
Patent number
US06774130B2

Reaction notes

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