Carbon tetrabromide → HCID 23500559, compound

HRID 1835752Notes

Reaction equation

HRID 1835752 reaction equation
O[CH2:2][CH2:3][CH2:4][CH:5]1[N:11]2[C:12](=[O:15])[O:13][N:14]=[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6]1.C(Br)(Br)(Br)[Br:17].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C(Cl)Cl>[Br:17][CH2:2][CH2:3][CH2:4][CH:5]1[N:11]2[C:12](=[O:15])[O:13][N:14]=[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6]1

Participants

5

Reactant 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 9815732HCID 9815732, compound

Product 1

HCID 23500559HCID 23500559, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the product of Example 11 in methylene chloride at 0° C. is added carbon tetrabromide and triphenylphosphine. The reaction is stirred for 2 hours and the solvent is removed under reduced pressure. The crude product is dissolved in an eluting solvent system and chromatographed to afford the title compound.

Workup

  1. customthe solvent is removed under reduced pressure
  2. dissolutionThe crude product is dissolved in an eluting solvent system
  3. customchromatographed

Sources & evidence

ORD record
ord-c77381131bc2482e86802923fa207d1a
Source dataset
uspto-grants-2004_08
Patent number
US06774126B2

Reaction notes

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