Hydrochloric Acid → HCID 9899683, compound

HRID 1835827Notes

Reaction equation

HRID 1835827 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:15]=[N:14][CH:13]=[C:12]([CH3:16])[N:11]=2)[CH:5]=[CH:6][CH:7]=1.[ClH:17]>C(Cl)Cl.C(OCC)C>[ClH:17].[F:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:15]=[N:14][CH:13]=[C:12]([CH3:16])[N:11]=2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 9899684HCID 9899684, compound

Product 1

HCID 9899683HCID 9899683, compoundYield 60%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

2-[(3-Fluorophenyl)ethynyl]-6-methylpyrazine (520 mg, 2.45 mmol) was dissolved in CH2Cl2 (3 mL), and the resulting solution was treated with HCl in diethyl ether (2.7 mL of a 1.0M solution, 2.7 mmol). The mixture was sonicated, and the solvent decanted. The remaining solid was dried under high vacuum to afford 2-[(3-fluorophenyl)ethynyl]-6-methylpyrazine hydrochloride (338 mg, 60% yield) as a light yellow solid. M.p. 62-63° C. 1H NMR (CDCl3, 300 MHz) δ 8.73 (s, 1H), 8.57 (s, 1H), 7.54-7.35 (m, 3H), 7.28-7.20 (m, 3H), 2.84 (s, 3H).

Workup

  1. customThe mixture was sonicated
  2. customthe solvent decanted
  3. customThe remaining solid was dried under high vacuum

Sources & evidence

ORD record
ord-932773eadeee49369210e576159f3f56
Source dataset
uspto-grants-2004_08
Patent number
US06774138B2

Reaction notes

Loading…