2-Bromo-4,6-Difluoroaniline → HCID 23500738, compound

HRID 1835844Notes

Reaction equation

HRID 1835844 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]=[C:10]([C:14]([NH:16][C:17]2[C:22]([F:23])=[CH:21][C:20]([F:24])=[CH:19][C:18]=2Br)=[O:15])[CH2:9]1)C1C=CC=CC=1.BrC1C=C(F)C=C(F)C=1N.C[O:37][C:38]([C:40]1CN(CC2C=CC=CC=2)CCC=1)=[O:39]>C1(C)C=CC=CC=1.C(#N)C.C(N(CC)CC)C>[C:38]([OH:39])(=[O:37])[CH3:40].[F:24][C:20]1[CH:19]=[C:18]2[C:10]3([CH2:11][CH2:12][CH2:13][NH:8][CH2:9]3)[C:14](=[O:15])[NH:16][C:17]2=[C:22]([F:23])[CH:21]=1

Participants

5

Reactant 3

HCID 1362852-Bromo-4,6-DifluoroanilineHCID 114475851-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid methyl esterHCID 23500666HCID 23500666, compound

Product 1

HCID 23500738HCID 23500738, compound

Reagents, catalysts & solvents 1

HCID 86592183HCID 86592183, compoundSolvent

Procedure

1-Benzyl-N-(2-bromo-4,6-difluorophenyl)-1,2,5,6-tetrahydropyridine-3-carboxamide. The title compound was prepared from 2-bromo-4,6-difluoroaniline and 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid methyl ester as described in EXAMPLE 1. Rf 0.53 (toluene/acetonitrile/tri-ethyl amine 10:10:1).

Sources & evidence

ORD record
ord-e805801351a14279b508cdb7f0e5985c
Source dataset
uspto-grants-2004_08
Patent number
US06774132B1

Reaction notes

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