Acetaldehyde → HCID 9859441, compound

HRID 1835845Notes

Reaction equation

HRID 1835845 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][C:3]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[NH:8][C:7]2=[O:15])[CH2:2]1.[CH:16](=O)[CH3:17]>>[CH2:16]([N:1]1[CH2:6][CH2:5][CH2:4][C:3]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[NH:8][C:7]2=[O:15])[CH2:2]1)[CH3:17]

Participants

3

Reactant 2

HCID 177AcetaldehydeHCID 9859066HCID 9859066, compound

Product 1

HCID 9859441HCID 9859441, compound

Procedure

The compound was prepared according to PROCEDURE 1, Method A by reaction with spiro[indoline-3,3′-piperidin]-2-one and acetaldehyde (5 equivalents). Yield: 45 mg (26%). 13C NMR of the HCl-salt (CD3OD): δ 9.6, 19.8, 31.3, 46.3, 54.2, 54.3, 55.1, 111.5, 123.9, 124.4, 130.4, 131.3, 142.6, 182.3.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-35ef0cf993d24348a2b86873d8a86571
Source dataset
uspto-grants-2004_08
Patent number
US06774132B1

Reaction notes

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