反应详情

A 500 mL round-bottomed flask equipped with a magnetic stirrer was charged with a solution of 4-benzyloxy-1-(2-fluorobenzenesulfonyl)-1H-indole (21.48 g, 0.056 mol) in 200 mL freshly distilled THF, followed by 5% palladium on carbon (0.100 g, 0.8 mol %). The flask was sealed with a rubber septum and purged with hydrogen gas at atmospheric pressure. The solution was stirred at ambient temperature for 6 hours. The catalyst was removed by filtration through celite, and the filtrate concentrated in vacuo. The resulting crude solid was recrystallized from ethyl ether (75 mL) to give 1-(2-fluorobenzenesulfonyl)-4-hydroxy-1H-indole as a white solid (6.55 g, 40%). MS: (M−H)−=290.1.

1. customA 500 mL round-bottomed flask equipped with a magnetic stirrer
2. customThe flask was sealed with a rubber septum
3. custompurged with hydrogen gas at atmospheric pressure
4. customThe catalyst was removed by filtration through celite
5. concentrationthe filtrate concentrated in vacuo
6. customThe resulting crude solid was recrystallized from ethyl ether (75 mL)