HCID 22221589, compound → HCID 22221592, compound

HRID 1836036Notes

Reaction equation

HRID 1836036 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:20](O)([CH3:22])[CH3:21])[C:6]2[O:10][C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[CH:8][C:7]=2[CH:19]=1>C1COCC1>[C:20]([C:5]1[C:6]2[O:10][C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[CH:8][C:7]=2[CH:19]=[C:3]([O:2][CH3:1])[CH:4]=1)([CH3:22])=[CH2:21]

Participants

3

Reactant 1

HCID 22221589HCID 22221589, compound

Product 1

HCID 22221592HCID 22221592, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-[5-Methoxy-2-(4-methoxy-phenyl)-benzofuran-7-yl]-propan-2-ol 115 (0.4 g, 1.3 mmol) and Burges Reagent (0.4 g, 1.7 mmol) in THF (10 ml) were heated to reflux. After 30 min, the reaction was cooled, concentrated and the product was purified by column chromatography on silica gel (10% EtOAc/Hexane) to give 116 as a solid (0.29 g, 77%).

Workup

  1. temperaturethe reaction was cooled
  2. concentrationconcentrated
  3. customthe product was purified by column chromatography on silica gel (10% EtOAc/Hexane)

Sources & evidence

ORD record
ord-4a1b890d30384e58a495c5a288bb7793
Source dataset
uspto-grants-2004_08
Patent number
US06774248B2

Reaction notes

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