HCID 22221592, compound → HCID 22221615, compound

HRID 1836037Notes

Reaction equation

HRID 1836037 reaction equation
[C:1]([C:4]1[C:12]2[O:11][C:10]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)=[CH:9][C:8]=2[CH:7]=[C:6]([O:21][CH3:22])[CH:5]=1)([CH3:3])=[CH2:2].[H][H]>CCO.C1COCC1.[Pd]>[CH:1]([C:4]1[C:12]2[O:11][C:10]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)=[CH:9][C:8]=2[CH:7]=[C:6]([O:21][CH3:22])[CH:5]=1)([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 22221592HCID 22221592, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22221615HCID 22221615, compoundYield 95.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21873804Tetrahydrofuran ethanolSolvent

Procedure

7-Isopropenyl-5-methoxy-2-(4-methoxy-phenyl)-benzofuran 116 (0.28, 0.95 mmol) was hydrogenated over an atmosphere of hydrogen with 10% Pd/C (0.05 g) in EtOH/THF (10 ml). After 2 hr, the reaction was filtered through celite and concentrated to give 117 as a solid (0.27 g, 95%).

Workup

  1. filtrationthe reaction was filtered through celite and
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-a74a73b62eb9428e93c1d2726c258d29
Source dataset
uspto-grants-2004_08
Patent number
US06774248B2

Reaction notes

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