Hydrochloric Acid → HCID 86617447, compound

HRID 1836093Notes

Reaction equation

HRID 1836093 reaction equation
[CH2:1]1[C:12]2[C:11]3[CH:10]=[CH:9][CH:8]=[C:7]([C:13]([NH:15][C@H:16]([CH3:21])[C:17]([O:19][CH3:20])=[O:18])=[O:14])[C:6]=3[NH:5][C:4]=2[CH2:3][CH2:2]1.Cl>CO.[Pd]>[CH2:1]1[CH:12]2[CH:4]([NH:5][C:6]3[C:7]([C:13]([NH:15][C@H:16]([CH3:21])[C:17]([O:19][CH3:20])=[O:18])=[O:14])=[CH:8][CH:9]=[CH:10][C:11]=32)[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86617448HCID 86617448, compound

Product 1

HCID 86617447HCID 86617447, compoundYield 55.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Following the procedure of method 7C, methyl (2R)-2-[(1,2,3,4-tetrahydrocyclopenta[b]indol-5-ylcarbonyl)amino]propanoate (4.9 mmol, 1.4 g) was hydrogenated using 5% Pd/C (1.5 g) and concentrated HCl (7 mL) in methanol (25 mL) to yield an oil (2.7 mmol, 0.77 g, 55%).

Sources & evidence

ORD record
ord-891deba4415b4b5d8306a6ad7b36d9f8
Source dataset
uspto-grants-2004_08
Patent number
US06777407B2

Reaction notes

Loading…