HRID1836136

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10176909

未命名化合物

结构：CCOC(=O)N1CCN(CCCc2c(C=O)[nH]c3c2CCCC3)CC1

HCID86588562

未命名化合物

PRODUCTS

生成物

$结构：CCOC(=O)N1CCN(CCCc2c(/C=C3\C(=O)Nc4ccc(S(=O)(=O)NC)cc43)[nH]c3c2CCCC3)CC1$

HCID23518513

未命名化合物

收率 61.5%

PROCEDURE

实验过程

4-[3-(2-Formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propyl]-piperazine-1-carboxylic acid ethyl ester (65 mg, 0.1 87 mmol) was condensed with 5-methylaminosulfonyloxindole (43 mg, 1.01 eq.) following the same condition used in Example 1 above. The precipitated solid was purified by flash chromatography, eluting with dichloromethan/methanol (50/1, 40/1, 30/1) to provide 65 mg of the desired product.

WORKUP

后处理

customThe precipitated solid was purified by flash chromatography
washeluting with dichloromethan/methanol (50/1, 40/1, 30/1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7d26c565f271451fa2f95c0b667051f8
来源数据集: uspto-grants-2004_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06777417B2
来源说明: uspto-grants-2004_08

反应 SMILES

[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][CH2:14][C:15]2[C:23]3[CH2:22][CH2:21][CH2:20][CH2:19][C:18]=3[NH:17][C:16]=2[CH:24]=O)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH3:26][NH:27][S:28]([C:31]1[CH:32]=[C:33]2[C:37](=[CH:38][CH:39]=1)[NH:36][C:35](=[O:40])[CH2:34]2)(=[O:30])=[O:29]>>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][CH2:14][C:15]2[C:23]3[CH2:22][CH2:21][CH2:20][CH2:19][C:18]=3[NH:17][C:16]=2/[CH:24]=[C:34]2\[C:35](=[O:40])[NH:36][C:37]3[C:33]\2=[CH:32][C:31]([S:28](=[O:29])(=[O:30])[NH:27][CH3:26])=[CH:39][CH:38]=3)[CH2:8][CH2:7]1)=[O:5])[CH3:2]