N-methyl-2-oxoindoline-5-sulfonamide → 4-(3-{2-[5-methylsulfamoyl-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-4,5,6,7-tetrahydro-1H-indol-3-yl}-propyl)-piperazine-1-carboxylic acid ethyl ester

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Reaction Steps

4-[3-(2-Formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propyl]-piperazine-1-carboxylic acid ethyl ester (65 mg, 0.1 87 mmol) was condensed with 5-methylaminosulfonyloxindole (43 mg, 1.01 eq.) following the same condition used in Example 1 above. The precipitated solid was purified by flash chromatography, eluting with dichloromethan/methanol (50/1, 40/1, 30/1) to provide 65 mg of the desired product.

Provenance & Evidence