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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1836139Generated: November 3, 2026

N-methyl-2-oxoindoline-5-sulfonamide → 3-[1-{3-[3-(4-Acetyl-piperazin-1-yl)-propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl}-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide

https://huagongshe.com/reaction/1836139

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-methyl-2-oxoindoline-5-sulfonamideHCID 10176909—
ReactantHCID 23498840HCID 23498840—
Product3-[1-{3-[3-(4-Acetyl-piperazin-1-yl)-propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl}-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamideHCID 2351850652.7%

Reaction Steps

3-[3-(4-Acetyl-piperazin-1-yl)-propyl]-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde (70 mg, 0.22 mmol) was condensed with 5-methylaminosulfonyl-oxindole (50 mg, 1.01eq.) under the same conditions used in Example 1 to give 61 mg of the desired product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06777417B2
Source datasetuspto-grants-2004_08
ORD IDord-97cf6937673242c19dc3799729afe713
Source noteuspto-grants-2004_08