HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-methyl-2-oxoindoline-5-sulfonamide → 3-[1-{3-[3-(4-Acetyl-piperazin-1-yl)-propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl}-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-methyl-2-oxoindoline-5-sulfonamide | HCID 10176909 | — |
| Reactant | HCID 23498840 | HCID 23498840 | — |
| Product | 3-[1-{3-[3-(4-Acetyl-piperazin-1-yl)-propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl}-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide | HCID 23518506 | 52.7% |
Reaction Steps
3-[3-(4-Acetyl-piperazin-1-yl)-propyl]-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde (70 mg, 0.22 mmol) was condensed with 5-methylaminosulfonyl-oxindole (50 mg, 1.01eq.) under the same conditions used in Example 1 to give 61 mg of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06777417B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-97cf6937673242c19dc3799729afe713 |
| Source note | uspto-grants-2004_08 |