HCID 23498840, compound → HCID 44299266, compound

HRID 1836140Notes

Reaction equation

HRID 1836140 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][CH2:12][C:13]2[C:21]3[CH2:20][CH2:19][CH2:18][CH2:17][C:16]=3[NH:15][C:14]=2[CH:22]=O)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[CH2:24]([S:26]([C:29]1[CH:30]=[C:31]2[C:35](=[CH:36][CH:37]=1)[NH:34][C:33](=[O:38])[CH2:32]2)(=[O:28])=[O:27])[CH3:25]>>[C:1]([N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][CH2:12][C:13]2[C:21]3[CH2:20][CH2:19][CH2:18][CH2:17][C:16]=3[NH:15][C:14]=2/[CH:22]=[C:32]2\[C:33](=[O:38])[NH:34][C:35]3[C:31]\2=[CH:30][C:29]([S:26]([CH2:24][CH3:25])(=[O:28])=[O:27])=[CH:37][CH:36]=3)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 23498840HCID 23498840, compoundHCID 23498854HCID 23498854, compound

Product 1

HCID 44299266HCID 44299266, compoundYield 65%

Procedure

3-[3-(4-Acetyl-piperazin-1-yl)-propyl]-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde (70 mg, 0.22 mmol), prepared as described in Example 10 above, was condensed with 5-ethylsulfonyloxindole (69.5 mg, 1.01 eq, 72% pure) following the procedure used in Example 1 above. The formed solid was purified by flash chromatography using (dichloromethane: methanol 50/1, 30/1) to give 75 mg of the desired product.

Workup

  1. customThe formed solid was purified by flash chromatography

Sources & evidence

ORD record
ord-29c596c0333f41c58379894e848cae72
Source dataset
uspto-grants-2004_08
Patent number
US06777417B2

Reaction notes

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